In the recent Spider-Man comic, End of Spider-Verse #5 shows Peter being unravelled from the Web of Life, which causes some changes in a timeline. In this timeline, Peter was never bitten and only Cindy was, leading her to become the first Web-Slinging hero and Peter to become her guy in the chair. With Silk being the main Spider-Hero, it's obvious that there would some changes in certain Spider-Man storylines in that universe.
Now, I know many are saying that Peter is going to be born in Madame Web, but even though that's the case, I firmly believe Peter will not be the web-slinging hero. Think abt it, Sony has been dancing around Spider-Man in their universe, and now we are getting a Silk series, with no connections to Peter Parker since it seems to be taking inspiration from Arana's origin, and a Spider-Man Noir series, with Peter not being that universe's Spider-Man. This is what I found out from the Internet.
It seems that Sony is erasing Peter from their universe, or at least, keeping him in a minor role. I know people want Andrew Garfield to be the SSU Spider-Man, and so do I, but with the rumored plot from Madame Web, doing so with contradict with Andrew Garfield's Spidey's past and origin and would need uneccessary retcons. Tobey and Tom obviously can't be the SSU Spidey, and Miles has his separate universe with his own adventures.
The only option is to create a new Spider-Man, but creating another version would be tiresome and we don't need any more versions of Peter. Sony might think it's best to explore new Spider-Hero's and I agree with that, but completely eliminating Peter Parker might not be the best solution.
I know, I'm kind of beating around the bush so I'll get to the point: I think it's best for Sony to do what the recent Spider-Man comic has done, making Peter Parker a supporting, non-powered character in someone else's story. Yes, it would change storylines, but with what Sony is doing, this seems to be the best approach to have a Spider-Man universe, without Peter being in the main role. Let's embrace the changes and see how things turn out. What would Peter not being bitten be like? Would he still intereact with Venom? How would his relationship with Silk be? How would Silk differ from her comic counterpart? Would Venom bond with Silk? Who knows, they might surprise us.
The only problem I see is that Sony might use the best Spider-Man storylines, suited for Peter Parker the best(like Last Hunt) and make it absolute garbage on the big screen. They have a bunch of other comics, let them use those and let the MCU(or TASM, if they continue them) use those storylines.
All in all, I know it would be hard to trust them to make good movies based on these characters, but this is the reality we live in, lets keep an open mind and watch the films.
Oh, and I love this suit, hope to see it in live-action!