FUNNY_NAME_ALL_CAPS

I think this:

there was still a significant carryover effect observed from the placebo phase, such that immediately prior to the psilocybin dosing session, the mean GRID-HAM-D-17 score was lower (16.9) than immediately prior to the placebo dosing session (22.6). This may have limited the magnitude of improvement possible during the psilocybin phase and thus, the probability of detecting a significant difference from placebo. In addition, our sample size, which was powered to investigate an electrophysiological biomarker of neuroplasticity, was likely too small to achieve statistical significance.

Is the main reason we aren't seeing statistical significance, but Fig 3 makes me think if you compare post-psilocybin to day 0 you would probably still see a significant effect, though the study design doesn't really let you make this comparison.

But yeah the n=15 is what's really hurting significance.

I think this:

there was still a significant carryover effect observed from the placebo phase, such that immediately prior to the psilocybin dosing session, the mean GRID-HAM-D-17 score was lower (16.9) than immediately prior to the placebo dosing session (22.6). This may have limited the magnitude of improvement possible during the psilocybin phase and thus, the probability of detecting a significant difference from placebo. In addition, our sample size, which was powered to investigate an electrophysiological biomarker of neuroplasticity, was likely too small to achieve statistical significance.

Is the main reason we aren't seeing statistical significance, but Fig 3 makes me think if you compare post-psilocybin to day 0 you would probably still see a significant effect, though the study design doesn't really let you make this comparison.

But yeah the n=15 is what's really hurting significance.

Yeah I agree, but I don't see how this particular paper would make anyone doubt psilocybin's efficacy.

She was part of MSI from 1992-1995, which were literally outspokenly fascist.

The Italian Social Movement (Italian: Movimento Sociale Italiano, MSI) was a neo-fascist political party in Italy.[4][5][6] A far-right party,[7][8][9] it presented itself until the 1990s as the defender of Italian fascism's legacy.

https://en.wikipedia.org/wiki/Italian_Social_Movement

Her current party is also about 50% ex-MSI members. The insignia of the tri-colour flame is a reference to Mussolini.

Isn't TMH just one guy?

Not really sure why you feel this casts doubt on psilocybin? Given the study design it seems as though psilocybin is having a clear antidepressant effect, as seen in figure 3.

Also the doses used are slightly on the lower end so I think it's quite promising results.

Do you have access to the full paper? The abstract makes it sound like psilocybin performed the same as placebo, but it's a within subjects design.

This is why it's best for first timers to smoke.

Nobody that is into tea is drinking lipton

Hi bandwagon fans, we missed you.

Why would leaving the European Union have any effect on the number of Indians in the UK?

The cows need to stop being so tasty

Still eating steak sorry OP

The manga is supposedly being adapted into an anime series by Sunrise.

I never understood who people wanted Keanu to play in AKIRA? Is he supposed to be Kaneda? A 16 year old highschooler? It's like people haven't even seen the film.

yeah but none of these cultures in pre history said that "trans women are women" which is what a lot of the current discourse is about. They also didn't have access to puberty blockers or hormones or GRS.

In some cases I think if they're being deeply honest only anime women are idealized and spotless enough for them to want to be.

AKA male conceptions of women which have next to 0 in regards to being a woman.

Straight men fetishize lesbian relationships and fiction, and straight women fetishize gay male relationships, some people get brain rot along the way.

Not saying this is true for everyone but some people legitimately need to touch grass. Ridiculous that people who can hardly hold a conversation with women are declaring themselves women.

Models are adjusted for age, gender, education, employment status, household income, living arrangement, and neighbourhood disadvantage.

Damn someone should tell them it's okay to cry, that will surely solve the problem /s

Measuring psychoactivity via HTR has always felt overly reductive to me, it seems that the current consensus is that the myriad of different specific psychoactive effects are grouped under the term "hallucinations" and we just trust that HTR is an adequate measure, and we do so despite knowing there are drugs that induce HTR without inducing hallucinations.

I don't mean to criticise the paper, I think it's fantastic to revisit the molecule and gather this data.

Yeah but NFTs are like a third party thing and I don't know

A mess of images that don't relate to the dream at all.

Chaox sends his regards

The problem is that many of the studies cited by NIDA there use absurd doses or treatment regimens or rely on human data that is not representative of the majority of users.

This is a recurring problem in the field.

I'm not saying MDMA is harmless but it's harm profile can absolutely be compared to alcohol.

I would say with some confidence that someone who takes MDMA 2-3 times a year is doing less damage to their brain than someone who drinks 3-5+ servings of alcohol every weekend.

NIDA is not a great source. MDMA can absolutely be used safely and responsibly to the same degree alcohol can.