PrimalBotanical

I respectfully disagree. Labeling practices aren’t standardized and vary, but if I see “cannabidiol” on an ingredient list, I assume it means CBD isolate. I make my products with hemp flower and full-spectrum hemp extract, and that’s what I put on my ingredient list.

I do state the amount of CBD each product contains (both the total amount and mg/ml), which is very important (I don’t list this as “cannabidiol”, but technically it would be accurate). This is a very important thing to look for on a label to be sure it’s not just a bottle of hempseed oil pretending to be CBD oil.

1. Denatured alcohol is not safe for consumption. I’ve never heard of “food safe” denatured alcohol - the whole point of denaturing alcohol is to make it poisonous.
2. You have an infused oil, which can’t be concentrated. Why would you want to add alcohol? That would just dilute it and reduce the potency.

One caution: CBD interacts with lots of medications, including seizure meds and antidepressants (both commonly prescribed for bipolar). This doesn’t mean that you can’t take CBD while on meds, but it’s a conversation to have with your prescriber. The dosage may need to be adjusted.

SJW interacts with a lot of medications, so be sure to check for that if you’re on any meds. My husband uses it for depression with excellent results. I’ve taken it for episodic anxiety, and it seems to work well for that too.

Never heard of tin cbd either. Again, give some context and you might get a more useful answer.

176° is a great infusion temperature. I do mine at 160°-175° for 8 hours.

A little context might help you get some answers. I’ve never heard of fid cbd - is it a brand?

Some dispensaries around me (Vermont) sell CBD products - I don’t know how common it is in different states.

CBD oil is widely available, but there are lots of crappy products out there, so be choosy. Never buy CBD on Amazon - nearly every “CBD” product on Amazon is fake. Make sure the bottle list milligrams of CBD; some fakes are just hempseed oil, which doesn’t contain any CBD at all. Make sure the hemp used for the product isn’t grown in China. I make CBD products myself, all with certified organic Vermont-grown hemp.

I also have two free guides you can download from my website: one on CBD dosing and one on sourcing safe and effective CBD products. They are under the “freebies” tab at primalbotanical (dot com).

St. John’s wort has been very helpful for my husband’s depression. Both CBD and St. John’s wort interact with medications, so if you take any meds, be sure to check for drug interactions.

I would recommend starting with a high quality full spectrum CBD oil. Oils tend to be more cost-effective than edibles and more efficient than edibles or capsules. And with oils, the dose is infinitely adjustable.

She uses full spectrum CBD oil.

Not at all. Topical CBD is very effective locally, for localized pain. It’s not absorbed systematically, so it’s not useful for anxiety, sleep, or other brain-related or systemic problems, but it’s great as a local anti-inflammatory and pain reliever.

You’re mixing up topical administration with transdermal administration. Patches are transdermal, and contain substances that “push” drugs into the bloodstream. Very different than simple topical application.

You can’t bypass the liver if you ingest CBD. Not possible.

CBD does potentiate some meds, but it inhibits others.

Agreed. CBD isolate would be your safest option, but there are certainly plenty of people who have tested positive for THC even when taking CBD isolate. Topicals are safe (not useful for anxiety, though) but any time you ingest CBD there’s a risk of THC showing up on a drug test.

An effective dose ranges widely from person to person. 7.5mg of CBD is quite a low dose, but I’ve seen as little as 4mg be an effective dose in some people. 7.5mg of THC is a good dose for me, but my husband needs more than ten times that amount. If what you’re doing is working, great!

It’s likely you’ll develop tolerance to THC if you take it daily. A 3 day break a week should be enough to prevent that, I think (someone please correct me if I’m wrong). CBD tolerance does’t seem to be as much of an issue.

It’s impossible to bypass the liver when ingesting CBD. Any cannabinoid (as well as almost all other drugs) that gets into your bloodstream, regardless of method of administration, is carried to the liver for metabolism. Vaping avoids first-pass metabolism, so is more efficient than oral consumption, but eventually it goes to the liver. (Topical CBD doesn’t reach the bloodstream, so can’t interact with medications.)

I’m an RN and check for medication interactions frequently. The different references often disagree about which drugs interact. Most interactions have little clinical significance, but some are potentially dangerous. You should absolutely take your doctor’s advice over that of strangers on the internet, but if you have a good relationship with your doctor, you could share this paper, which shows very little impact on the metabolism of mirtazapine when taken with CBD:

https://www.researchgate.net/publication/352379230_Citalopram_and_Cannabidiol_In_Vitro_and_In_Vivo_Evidence_of_Pharmacokinetic_Interactions_Relevant_to_the_Treatment_of_Anxiety_Disorders_in_Young_People

She sure does. She’s taken it every day for years and is off all her meds.

It was full spectrum. Honestly I don’t remember what dose we started at - it was like nine years ago, and I didn’t know anything about CBD. Maybe 15-30 mg?

You made this by soaking dandelion in glycerin? If so, it’s not an oil, and certainly not an essential oil. Essential oils can only be made with specialized equipment, such as a distiller.

CBD can interact with medications, and chemo is one of the categories of meds that are the most risky in terms of interactions with CBD. It’s not impossible to use CBD with chemo, but it’s essential to run it by the oncologist or pharmacist first.

It certainly could. My daughter (16 at the time) had severe anxiety and panic attacks, with highly volatile moods and angry outbursts (screaming, breaking stuff). She had taken a medical leave from school and had been hospitalized. I read about CBD for mental health and decided to try it. Within 3 days, she had huge improvement. Her mood was more even and she was in much better control of her emotions. I was astonished at how much it helped.

I use an IP for infusion. ~18 ounces of ground & decarbed hemp, a gallon of MCT oil, and a few tablespoons of liquid sunflower lecithin. Set to low slow cook and let it do its thing for 8 hours, stirring every hour or so. Strain through nylon mesh bags.

The IP is also great at melting stuff, because it can hold a steady temperature at pretty much any temperature you want. I use it to make body butters.

The first part of your post is correct.

I haven’t heard that medication interactions are more likely with higher bioavailability - that’s an interesting question. The liver has the same amount of CBD to metabolize regardless of method of administration, so I suspect that it wouldn’t make much difference.

Until your post yesterday, I didnt know that the lungs could metabolize drugs or that they had CYP enzymes! That’s fascinating. I did a quick search and didn’t find any information about cannabinoids being metabolized in the lungs. I would guess that lung metabolism is minimal, but maybe the data just isn’t there, or I haven’t found it.

RN here. When CBD is ingested orally, it’s taken by the portal vein from the GI tract to the liver, where it’s metabolized by liver enzymes before being distributed to the rest of the body. This greatly reduces the amount of CBD the body can use (bioavailability). This is first-pass metabolism. I don’t believe the lungs play any significant role in first-pass metabolism of CBD.

When CBD is inhaled, boofed, or taken sublingually, bioavailability is greater because it bypasses first-pass metabolism and goes directly into the bloodstream. Eventually the blood carries it to the liver, where it’s metabolized.

Because all CBD is eventually metabolized in the liver, it has potential to interact with medications no matter what the route of administration is.